Bioequivalent pharmacokinetics for generic and originator hepatitis C direct-acting antivirals
نویسندگان
چکیده
منابع مشابه
Mechanisms of Hepatitis C Viral Resistance to Direct Acting Antivirals
There has been a remarkable transformation in the treatment of chronic hepatitis C in recent years with the development of direct acting antiviral agents targeting virus encoded proteins important for viral replication including NS3/4A, NS5A and NS5B. These agents have shown high sustained viral response (SVR) rates of more than 90% in phase 2 and phase 3 clinical trials; however, this is sligh...
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BACKGROUND & AIMS Availability of directly-acting antivirals (DAAs) has changed the treatment landscape of hepatitis C virus (HCV) infection. The high price of DAAs has restricted their use in several countries. However, in some countries such as India, generic DAAs are available at much cheaper price. This study examined whether generic DAAs could be cost-saving and how long it would take for ...
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or a number of years, immunologists have strived to Funderstand the mechanisms associated with treatment-induced eradication of hepatitis C virus (HCV). However, interferon (IFN)-a–based therapies did not allow studies examining the role of the virus itself on innate and adaptive immunity to HCV. The study by Serti et al published in this issue of Gastroenterology provides a unique opportunity ...
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BACKGROUND Despite recent advances in hepatitis C (HCV) treatment, specifically the addition of direct acting antivirals (DAAs), pegylated interferon-alpha remains the backbone of HCV therapy. Therefore, the impact of DAAs on the management of co-morbid psychiatric illness and neuropsychiatric sequalae remains an ongoing concern during HCV therapy. This paper provides a review of the neuropsych...
متن کاملDirectly acting antivirals against hepatitis C virus.
The approval of directly acting antivirals (DAA) for the treatment of chronic hepatitis C virus (HCV) infection will represent a major breakthrough for the 180 million persons infected worldwide. Paradoxically, hepatitis C is the only human chronic viral disease that can be cured, as all other pathogenic viruses infecting humans either display self-limited courses or establish non-eradicable pe...
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ژورنال
عنوان ژورنال: Journal of Virus Eradication
سال: 2018
ISSN: 2055-6640
DOI: 10.1016/s2055-6640(20)30257-0